Mesothelioma

Saturday, January 24, 2009

Epithelioid, Sarcomatoid and Biphasic Mesothelioma Cancer Cell Types

Malignant mesothelioma is generally divided into three histological categories, or types of cells: epithelioid, sarcomatoid and biphasic mesothelioma. Within each of these mesothelioma cancer cell types, subtypes exist. Many mesothelioma patients display more than one cell type.

The diagnosis of mesothelioma cannot be specifically by lung x-rays or other types of imaging, because many different types of cancer can be present in the lungs. The images show only that a tumor may be present, but does not provide an indication of whether the tumor is mesothelioma. A biopsy must be performed where the mesothelioma cancer cell types are used to distinguish mesothelioma from other types of cancer, such as lung cancer.

Epithelioid Mesothelioma Cancer

Epithelioid mesothelioma is the most common cell type, constituting approximately 50% to 70% of all malignant mesothelioma. These cells are relatively uniform in shape and have a tubular pattern with a distinct cell nucleus. The individual cells are shaped like cubes or multi-sided boxes.

Because of the similarity between adenocarcinoma and mesothelioma cancer cells, they are often confused and mesothelioma can be misdiagnosed. Inspection of the cancer cells under high-powered microscopes and identification of unique characteristics of the chemical properties of the cells can help make the proper diagnosis. Learn more about epithelioid mesothelioma cancer.

Sarcomatoid Mesothelioma Cancer

Sarcomatoid mesothelioma is the least common type of mesothelioma cancer cell and accounts for approximately 10% to 15% of malignant mesothelioma. These cells typically have more of an oval, irregular shape and the nucleus of each cell is not as visible with a microscope as the epithelioid mesothelioma cancer cells. Because of the similarity of appearance, the sarcomatoid cancer cells can also easily be confused with the more typical sarcoma cancer cells. Learn more about sarcomatoid mesothelioma cancer.

Biphasic Mesothelioma Cancer

Approximately 20% to 40% of the mesothelioma cancer cells fall into the biphasic category, which is combination of the sarcomatoid and epithelioid types. The biphasic type can occur with the two types of cells intermixed continuously throughout the tumor, or with them in specific groupings. Transitional areas between the two cell types are often present. Learn more about biphasic mesothelioma cancer.

Prognosis Based on Cell Type

The mesothelioma cancer cell type does affect the prognosis. A study conducted on 167 patients showed that patients had the following mean survival times:

epithelioid	8.5 months
sarcomatoid	7 months
biphasic	6 months

Treatment options are very similar for patients with the different cell types.

[Page updated September 2005]

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Primary Lung Cancer and Secondary Lung Cancer - Mesothelioma

Cancer is a disease related to the uncontrolled growth of tissue, leading to the accumulation of mass (called a tumor or lesion.) Normal cells in the body divide and grow in an orderly controlled manner. When cells grow uncontrollably and this growth invades other tissues or organs, the growths are called malignant or cancerous. When a mass of tissue, or tumor, is benign, it is relatively stable and does not invade other tissues.

Cells from malignant tumors can break away and travel to other parts of the body, usually through the bloodstream, but also through the lymph system. When these cells find new host organs, these cells can grow into tumors in the new tissue. This spreading process is called metastasis and when a cancer has reached an advanced stage to where the malignant cells are attacking other organs, it is said that the cancer tumors have metastasized. The tumors in new organs are always made up of cells similar to those of the original tumor.

Benign tumors do not metastasize. They can often times be removed through surgery and not re-occur.

Lung Cancer

Lung cancer occurs when lung tissue develops cancerous growths. Primary lung cancer is cancer that originates in the lung tissue. Secondary lung cancer is cancer that spreads, or metastasizes, from other organs.

Primary Lung Cancer

There are several different types of primary lung cancer. These are divided into two main groups:

Small Cell Lung Cancer
Non-small Cell Lung Cancer

Pleural mesothelioma is often thought of as a third type of primary lung cancer. However, it is not a lung cancer. Mesothelioma does not develop in the lungs, but in the serous membranes surrounding the lungs. As such, it does not fall into the typical categories of lung cancer. Mesothelioma can also occur in other tissues, in the lining of the abdomen, call peritoneal mesothelioma, and in the lining of the heart, pericardial mesothelioma.

Small Cell Lung Cancer

Small Cell Lung Cancer comprises approximately 20% of the primary types of lung cancer. It is called small cell cancer because the tumor cells are very small, with the cells containing almost exclusively the cell nucleus and nothing more. This type of cancer is also referred to as �oat cell� cancer. Chemotherapy is often suggested for this cancer in the early stages because of the rapid way it which it spreads. Surgery is not a good option to stop the spread early on. This type of cancer is most closely linked to smoking; non smokers rarely have it.

Non-Small Cell Cancer

Non-small cell cancer falls into these categories:

Squamous cell carcinoma
Adenocarcinoma
Large cell carcinoma
Adenosquamous cell carcinoma
Undifferentiated carcinoma

Each category of non-small cell cancer are physiologically similar and they respond to treatment differently than to small cell lung cancer.

Squamous cell carcinoma is a common type of primary lung cancer. This type of cancer is also linked to smoking and it develops from the cells than line the airways in the lungs. Squamous cells are thin, flat cells that look like fish scales. Commonly the tumor growths are located in the center of the lungs near the large airways (bronchi). It is also referred to as epidermoid carcinoma. It comprises approximately 30 to 35% of the non-small cell cancer in the US, affecting men and the elderly most frequently.

Adenocarcinoma, like squamous cell carcinoma, develops from tissues in the lung airways. But, it develops from the glandular secretory tissues. (tissues that produce mucus). It is often found in the outer airway passages, not the main bronchi, like the squamous cell variety. The incidence of this cancer is increasing. It comprises about 40% of the non-small cell lung cancer in the US and is the most common lung cancer among women.

Large cell lung cancer is named after its appearance. The cells look large and unnatural under the microscope. These types of cells grow quite quickly.

Adenosquamous carcinoma are cells that appear flat under the microscope, like the squamous cells, but derive from the glandular secretory cells, like the adenocarcinoma.

Undifferentiated carcinoma includes cancer cells that cannot be identified as one of the other groups. The cells appear abnormal under the microscope and multiply uncontrollably.

Secondary Lung Cancer

Secondary lung cancer is cancer that has spread to the lungs from other organs. Many different types of cancer spread to the lungs, because of its very high blood supply. These include breast cancer and colon cancer.

The type of cancer is very important when it comes to treatment. The different types of cancer cells respond differently to different types of chemotherapy and other therapies. When cancer cells spread from other organs to the lungs, then the lungs have to be treated for the other type of cancer, not lung cancer. This is an important distinction. For example, breast cancer that spreads to the lungs, has to be treated for breast cancer, not lung cancer.

[Page updated July 2005]

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Types of Mesothelioma

Mesothelioma cancer affects the serous membranes that surround the major organs in the midsection of the body. Different organs can be affected by mesothelioma because the serous membranes surround the lungs, heart, abdomen and others. The most common type of mesothelioma is that which affects the lung lining, and is called pleural mesothelioma. Other types are pericardial mesothelioma, which affects the lining of the heart, and peritoneal mesothelioma, affecting the lining of the abdomen.

Mesothelioma, contrary to what many people think, is not a type of primary lung cancer. That is, mesothelioma does not originate in the lungs, but as described above, it starts in the serous membranes or lining around the lungs (or other organs). However, mesothelioma can spread to the lungs and when this occurs, it is considered to be a secondary lung cancer. Mesothelioma is also commonly referred to as an asbestos lung cancer. Technically, this is also incorrect, since mesothelioma does not originate in the lungs. Asbestosis is a type of asbestos lung disease that is often confused with mesothelioma.

Pleural Mesothelioma

Pleural mesothelioma represents about 75% of all mesotheliomas. The disease can grow quickly and enlarge the pleural space, causing it to fill with fluid. This fluid leads to the discomfort or pain associated with first detection of the disease. It is thought that pleural mesothelioma is caused by the inhaling of fibrous materials, including asbestos. These fibers lodge in the pleura and, over time, cause damage to the tissue layer and cancer erupts. Learn more about pleural mesothelioma.

Pericardial Mesothelioma

The rarest form of mesothelioma is that which affects the linings of the heart cavity, called the pericardium. Less than 10% of all mesothelioma cases are related to the heart. As in the lung, the rapid growth of the cancerous tumors can cause expansion of the tissue and accumulation of fluid. The fluid can interfere with the functioning of the heart and cause chest pain. Mesothelioma cases are known to be caused by exposure to asbestos; but it is completely unknown how the asbestos fibers enter the tissue layers surrounding the heart. Learn more about pericardial mesothelioma.

Peritoneal Mesothelioma

Mesothelioma of the abdomen is called peritoneal mesothelioma. The serous membrane surrounding the abdomen is known as the peritoneum. This disease accounts for approximately 10% to 20% of mesothelioma cases. In addition, a rare form of peritoneal mesothelioma affects the male testicles. The covering layer of the scrotum is actually an outpouching of the peritoneum. Peritoneal mesothelioma is due to the ingestion of fibrous materials, including asbestos. Learn more about peritoneal mesothelioma.

[Page updated February 2005]

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Mesothelioma and Compensation -- Who is Responsible?

Compensation is the greatest factor that drives people; it is considered as the greatest motivator of all things. Yet, compensation instigates more than plain monetary satisfaction. Above all things, it can give back whatever was lost.

Such is the case with mesothelioma and compensation. People who have acquired mesothelioma deem it necessary to receive the proper compensation they deserve. Why? Simply because it is not their intention to get sick with mesothelioma.

What is Mesothelioma?

Mesothelioma refers to progressive growth of malignant cells found in the mesothelium, a thin sheet that covers and protects the vital organs of the body, such as the lungs.

mesothelioma cancer picture Cancerous cells are described as malignant neoplasms. They demonstrate uncontrolled cell growth that follows no physiologic demand. When an abnormal cell is transformed by the genetic mutation of the cellular DNA, cancerous cells are formed. The cells infiltrate the tissues that surround them and gain access to lymph and blood vessels, which carry the cells to other areas of the body.

Normally, cancerous cells that develop in the mesothelium and eventually lead to mesothelioma are caused by glass-like particles that stick in the lungs. These particles come from asbestos, the common element used in building infrastructures. Asbestos is very popular in the industrial and construction field because of its high resistance against fire.

People who are exposed to asbestos have been found out to be the common patients diagnosed with mesothelioma. This is because the particles from asbestos that stick within the lungs tend to create cancerous cells. The damage caused by the process develops a disease process that triggers the growth of cancerous cells, where cell membranes are altered.

Overview of Mesothelioma and Compensation

Statistics show that nearly 80% of people afflicted with mesothelioma were working in the industrial field and construction area. Although mesothelioma is not a single disease with a single cause, the greatest common factor in developing the disease is asbestos.

Hence, society deems it necessary for these industries or employers, in general, to be responsible in providing the right compensation to their employees.

Issues on mesothelioma and compensation focus more on the privileges endowed to employees who have been sick with mesothelioma after being exposed to asbestos at work. The underlying connection between mesothelioma and compensation is seen in the lawsuits filed against the employers. Generally, these legal actions are done to claim financial damages from the company, who is entirely accountable for the safety of their employees working environment and for the implementation of safety gear against such hazards as asbestos.

Compensation for mesothelioma cases usually covers medical bills and other expenses related to mesothelioma, such as loss for daily wages or inability to provide their family with the quality life due to their non-working status.

People who are generally entitled for mesothelioma compensation are those who worked in the building, custodial, construction, shipyard, and automotive industry.

More information about mesothelioma and compensation:

1. It must be a cancer

Not everyone who had been exposed to asbestos can immediately file for mesothelioma compensation. The number one factor to consider for such claims is the development of cancer. The gravity of asbestos exposure will determine the condition that states one's eligibility for mesothelioma compensation.

2. Find a good lawyer

Not all mesothelioma lawyers can help you in claiming your compensation. Moreover, most mesothelioma lawyers that render services for mesothelioma compensation charge high fees. Hence, not everybody can afford to hire a mesothelioma lawyer.

However, some lawyers are willing to provide a "no win, no pay" agreement. By the time they win the case, the lawyer shares a certain percentage on the compensation. Hence, it is best that you find a good lawyer for you to obtain the right claims for you.

3. State laws

Mesothelioma compensation may vary from one state to another. This means that the existing state laws regarding mesothelioma lawsuits will be applicable only within its jurisdiction. Hence, not all provisions stated in a certain mesothelioma compensation are applicable on the other mesothelioma cases in different states.

Indeed, mesothelioma compensation can be very helpful in answering financial problems caused by mesothelioma. Reports show that mesothelioma patients can claim as much as $3 million. So if you have been diagnosed with mesothelioma, file your mesothelioma compensation now.

Mesothelioma

ASBESTOS CANCER (MESOTHELIOMA) & ASBESTOSIS

Asbestosis

Asbestosis is a non-cancerous, chronic lung illness caused by exposure to asbestos.

Significant exposure to asbestos increases the risk of lung cancer, mesothelioma and non-malignant lung and pleural disorders.

Risk depends on duration, frequency, concentration, & type of asbestos fibres.

Diseases from asbestos exposure take a long time to develop. Most cases of asbestosis occur in asbestos workers 15 or more years after initial exposure to asbestos.

Smoking greatly increases the likelihood of lung cancer in workers exposed to asbestos (although smoking does not appear to increase the risk of mesothelioma).

Mesothelioma (asbestos cancer)

Mesothelioma is a rare cancer which may affect the lining of the lungs (pleura) and the abdominal cavity (peritoneum).

Most mesotheliomas are caused by exposure to asbestos.

Most cases of mesothelioma are diagnosed 30 years or more after the first exposure to asbestos.

Mesothelioma occurs more often in men than in women.

Risk increases with age.

Symptoms & Signs

Shortness of breath (this is the primary symptom)

A persistent and productive cough

Chest tightness

Chest pain

Loss of appetite/weight loss

A crackling sound in the lungs while inhaling.

Diagnosis

History of asbestos exposure.

Chest X-rays are the most common method of detecting asbestos-related disorders.

Other tests:

Physical Examination
Pulmonary Function Tests
Biiopsy/Bronchoscopy
CT scan

Treatment

Treatment for mesothelioma depends on the location of the cancer, the stage of the disease, and the patient's age and general health. Standard treatment options include surgery, radiation therapy, and chemotherapy. Sometimes, these treatments are combined.

Getting Help

Only a doctor can make the diagnosis of mesothelioma. It is important to see a doctor if you have been exposed to asbestos and have any symptoms.